Which constellation is Spica located in?

Spica is located in the constellation Virgo, making this the correct choice. Virgo is one of the largest constellations in the sky and is often associated with the harvest and fertility, represented as a maiden holding sheaves of wheat. Spica itself is the brightest star in Virgo and serves as a significant marker for locating other constellations and stars in the night sky due to its distinct bluish color and brightness.

For context, Leo, Scorpius, and Cassiopeia are distinct constellations with their own notable stars and features. Leo is known for its lion shape and contains the bright star Regulus. Scorpius is recognized by its scorpion shape and includes the bright star Antares. Cassiopeia is easily identifiable by its W shape and features several bright stars, but none of these constellations include Spica. Therefore, Virgo is firmly established as the region of the sky in which Spica resides, reinforcing its significance not only as a star but also within the context of constellation identification in astronomy.